Clemente Suárez, Vicente JavierMartín Rodríguez, AlexandraBeltrán Velasco, Ana IsabelRubio Zarapuz, AlejandroMartínez Guardado, IsmaelValcárcel Martín, RobertoTornero Aguilera, José Francisco2026-07-232026-07-232025Clemente-Suárez, V. J., Martín-Rodríguez, A., Beltrán-Velasco, A. I., Rubio-Zarapuz, A., Martínez-Guardado, I., Valcárcel-Martín, R., & Tornero-Aguilera, J. F. (2025). Functional and therapeutic roles of plant-derived antioxidants in type 2 diabetes mellitus: Mechanisms, challenges, and considerations for special populations. Antioxidants, 14(6), 725. https://doi.org/10.3390/antiox140607252076-3921https://hdl.handle.net/11268/17310Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, oxidative stress, and inflammation, contributing to insulin resistance and long-term complications. Dietary antioxidants from plant sources, such as polyphenols, flavonoids, carotenoids, and phenolic acids, have been increasingly studied for their potential to modulate these pathophysiological mechanisms. This review aims to summarize and critically analyze the current evidence on the biological effects, therapeutic potential, and translational challenges of plant-derived antioxidants in the prevention and management of T2DM.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Diabetes mellitus tipo 2AntioxidantesEstrés oxidativojournal article10.3390/antiox14060725open accessLucha contra las enfermedadesInvestigación médicaMedicina preventivaGoal 3: Ensure healthy lives and promote well-being for all at all ages