Eynon, NirRuiz, Jonatan R.Meckel, YoavMorán, MaríaLucía Mulas, Alejandro2013-11-272013-11-272011Eynon, N., Ruiz, J. R., Meckel, Y., Morán, M., & Lucía-Mulas, A. (2011). Mitochondrial biogenesis related endurance genotype score and sports performance in athletes. Mitochondrion, 11(1), 64-69.18728278http://hdl.handle.net/11268/549We determined the probability of individuals having the 'optimal' mitochondrial biogenesis related endurance polygenic profile, and compared the endurance polygenic profile of Israeli (Caucasian) endurance athletes (n = 74), power athletes (n = 81), and non-athletes (n = 240). We computed a mitochondrial biogenesis related 'endurance genotype score' (EGS, scoring from 0 to 100) from the accumulated combination of six polymorphisms in the PPARGC1A-NRF-TFAM pathway. Some of the variant alleles of the polymorphisms studied were so infrequent, that the probability of possessing an 'optimal' EGS (= 100) was 0% in the entire study population. However, the EGS was significantly higher (P<0.001) in endurance athletes (38.9 ± 17.1) compared with controls (30.6 ± 12.4) or power athletes (29.0 ± 11.2). In summary, although the probability of an individual possessing a theoretically 'optimal' genetic background for endurance sports is very low, in general endurance athletes have a polygenic profile that is more suitable for mitochondrial biogenesis.engPolymorphism, Genetic*Athletic Performance/*PhysiologyEuropean Continental Ancestry Group/*GeneticsMitochondria/*GeneticsPhysical Endurance/*GeneticsTranscription Factors/*GeneticsAthletesFemaleGene FrequencyGenotypeHeat-Shock Proteins/GeneticsHumansIsraelMaleMiddle AgedMitochondria/MetabolismPpar Delta/GeneticsPhysical Endurance/PhysiologySportsTranscription Factors/Metabolismjournal article10.1016/j.mito.2010.07.004restricted accessGenética humana