Nin, NicolásLorente Balanza, José ÁngelFernández Segoviano, P.Paula, Marta deFerruelo, AntonioEsteban, Andrés2015-07-162015-07-162009Nin, N., Lorente, J. A., Fernández-Segoviano, P., dee Paula, M., Ferruelo, A., & Esteban, A. (2009). High-tidal volume ventilation aggravates sepsis-induced multiorgan dysfunction in a dexamethasone-inhibitable manner. Shock, 31(4), 429-434.1073232215400514http://hdl.handle.net/11268/4202High-tidal volume (Vt) ventilation induces lung injury and systemic inflammation, and small doses of endotoxin have been shown to increase the susceptibility to ventilation-induced lung injury. We studied whether high-Vt ventilation increases organ injury in a model of bacterial sepsis and whether an anti-inflammatory treatment averts those changes. Anesthetized rats, monitored with an arterial catheter and a blood flow probe in the aorta, were assigned to one of four different groups: nonseptic low-Vt group (Vt = 9 mL/kg, positive end-expiratory pressure = 8 cm H2O, control group), septic low-Vt group, septic overventilated group (Vt = 35 mL/kg, positive end-expiratory pressure = 0), and septic overventiled group pretreated with dexamethasone (6 mg/kg i.p., 30 min before mechanical ventilation).engSepsisBacteriasjournal article10.1097/SHK.0b013e318188b720restricted accessFallo multiorgánicoEnfermedad cardiovascularBacterias