Frías García, RaquelMuñoz García, PatriciaMachado Vílchez, MarinaCuerpo Caballero, GregorioRodríguez García, RaquelRodríguez Esteban, María ÁngelesFariñas Álvarez, María del CarmenMiró Meda, José MaríaGutiérrez Villanueva, AndreaOjeda Burgos, Guillermoet al.2025-05-272025Frías García, R., Muñoz García, P., Machado Vilchez, M., Cuerpo Caballero, G., Rodríguez-García, R., Rodríguez-Esteban, M. Á., Fariñas-Álvarez, M. C., Miró Meda, J. M., Gutiérrez Villanueva, A., Ojeda-Burgos, G., Goikoetxea-Agirre, A. J., Bernal Palacios, M., Martínez-Sellés, M., on behalf of the Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis Infecciosa en España (GAMES), Sánchez, F. F., Lomas, J. M. G. D., Rosas, G., Lima, J. D. L. T., Bereciartua, E., … Sanz, A. M. (2025). Body mass index and prognosis of infective endocarditis. Infectious Diseases, 1-8. https://doi.org/10.1080/23744235.2025.24819142374-4235http://hdl.handle.net/11268/14662Background and objectives: Malnutrition is associated with prognosis in several heart diseases, but there is little information in patients with infective endocarditis (IE). Our objective was to assess the influence of body mass index (BMI) on the prognosis of IE. Methods: National registry of patients with definite or probable IE from 2008 to 2021, comparing in- hospital and 1-year mortality according to BMI. Results: From 3645 patients, 91 (2.5%) were underweight, 1432 (39.3%) had normal weight, 1503 (41.2%) were overweight, and 619 (17.0%) had obesity. The median age was lowest in the under-weight group (51 vs. >66 years in the other groups, p < 0.001). Patients with underweight/normal weight had an inferior age-adjusted Charlson comorbidity score than those with overweight/obesity (4 vs. 5, p < 0.001). Tricuspid IE was common in patients with underweight (15.4%), while in other groups its prevalence was <6%, p < 0.001. In-hospital and 1-year mortality were respectively: underweight (26.4% and 34.1%), normal weight (19.9% and 25.8%), overweight (22.4% and 27.8%), and obesity(27.8% and 32.5%), both p values ≤ 0.01. In multivariate analysis, underweight showed a trend for an association with in-hospital mortality (odds ratio 1.67; 95% confidence interval 0.93–3.01 p =0.09) and a significant association with 1-year mortality (hazard ratio 1.94; 95% confidence interval 1.14–3.31; p =0.015). Conclusions: The prognosis of IE in patients with underweight and obesity is worse than in those with normal weight or overweight, and low weight is an independent predictor of 1-year mortality.engEndocarditisPronósticoÍndice de Masa Corporaljournal article10.1080/23744235.2025.2481914embargoed accessCiencias médicasNutriciónEnfermedad cardiovascularGoal 3: Ensure healthy lives and promote well-being for all at all ages