Sánchez-Menéndez, ClaraRodríguez-Pérez, JaimeFuertes, DanielLeguizamon, ValentinaGonzález-Sanmartin, MaríaMateos, ElenaCervero, MiguelSan José Martínez, EstherSanz, GonzaloÁlvaro, EdurneEt. al.2025-12-152025-12-152025Sánchez-Menéndez, C., Rodríguez-Pérez, J., Fuertes, D., Leguizamon, V., González-Sanmartín, M., Mateos, E., Cervero, M., San José, E., Sanz, G., Álvaro, E., Ballestero-Pérez, A., Martí-Gallostra, M., Rueda, J. A., Hurtado-Caballero, E., Pastor, C., Balaguer, F., Spinelli, A., Martínez-Laso, J., Torres, M., … Coiras, M. (2025). Differences in the peripheral blood immune landscape between early-onset and late-onset colorectal cancer. Frontiers in Immunology, 16, 1692382. https://doi.org/10.3389/fimmu.2025.16923821664-3224https://hdl.handle.net/11268/16617This study aims to discover novel immune biomarkers specific to EOCRC that may permit the development of a non-invasive, peripheral blood-based “liquid Immunoscore” that may integrate specific quantitative measurements. By contrasting the immune landscapes of EOCRC and LOCRC based on key immune cell subsets, exhaustion markers, soluble cytokines, and metabolic capacity, we seek to improve early detection, enable more timely and personalized treatment, and ultimately identify individuals under 50 at high risk for EOCRC before tumors become clinically detectable.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Neoplasias colorrectalesDiagnóstico precozInmunidadjournal article10.3389/fimmu.2025.1692382open accessCáncerMedicina preventivaInvestigación médicaGoal 3: Ensure healthy lives and promote well-being for all at all ages