Abumayyaleh, MohammadNúñez Gil, Iván JavierEl-Battrawy, IbrahimEstrada, VicenteBecerra Muñoz, Víctor ManuelFernández Rozas, InmaculadaFeltes, GiselaArroyo Espliguero, RamónRomero Pareja, RodolfoAkin, IbrahimEt al.2022-11-202022-11-202021Abumayyaleh, M., Nuñez-Gil, I. J., El-Battrawy, I., Estrada, V., Becerra-Muñoz, V. M., Uribarri, A., Fernández-Rozas, I., Feltes, G., Arroyo-Espliguero, R., Trabattoni, D., López Pais, J., Pepe, M., Romero, R., Ortega-Armas, M. E., Bianco, M., Astrua, T. C., D'Ascenzo, F., Fabregat-Andres, O., Ballester, A., Marín, F., … Akin, I. (2021). Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score. Frontiers in Medicine, 8, 728102. https://doi.org/10.3389/fmed.2021.7281022296-858Xhttp://hdl.handle.net/11268/11671Background: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19. Methods: We conducted a sub-analysis from the international Health Outcome Predictive Evaluation Registry for COVID-19 (HOPE-COVID-19-Registry, NCT04334291). Out of 5,837 patients with COVID-19, 624 patients were diagnosed with sepsis according to the Sepsis-3 International Consensus. Results: In multivariable analysis, the following risk factors were identified as independent predictors for developing sepsis: current smoking, tachypnoea (>22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO2) <92%, blood pressure (BP) (systolic BP <90 mmHg and diastolic BP <60 mmHg), Glasgow Coma Scale (GCS) <15, elevated procalcitonin (PCT), elevated troponin I (TnI), and elevated creatinine >1.5 mg/dl. By assigning odds ratio (OR) weighted points to these variables, the following three risk categories were defined to develop sepsis during admission: low-risk group (probability of sepsis 3.1–11.8%); intermediate-risk group (24.8–53.8%); and high-risk-group (58.3–100%). A score of 1 was assigned to current smoking, tachypnoea, decreased SpO2, decreased BP, decreased GCS, elevated PCT, TnI, and creatinine, whereas a score of 2 was assigned to hemoptysis. Conclusions: The HOPE Sepsis Score including nine parameters is useful in identifying high-risk COVID-19 patients to develop sepsis. Sepsis in COVID-19 is associated with a high mortality rate.engInfecciones por coronavirusjournal article10.3389/fmed.2021.728102open accessEnfermedad transmisiblePaciente