García Chico, CeliaPlaza Florido, AbelLópez Ortiz, SusanaPinto Fraga, JoséMaroto Izquierdo, SergioKhoramipour, KayvanSagarra Romero, LucíaFiuza Luces, María del CarmenLucía Mulas, AlejandroSantos Lozano, Alejandro2026-07-312026-07-312025García-Chico, C., Plaza-Florido, A., López-Ortiz, S., Pinto-Fraga, J., Maroto-Izquierdo, S., Khoramipour, K., Sagarra-Romero, L., Fiuza-Luces, C., Lucia, A., & Santos-Lozano, A. (2025). Proteomics signatures of human breast cancer: A systematic review. Critical Reviews in Oncology/Hematology, 216, 104950. https://doi.org/10.1016/j.critrevonc.2025.1049501040-84281879-0461https://hdl.handle.net/11268/17348Proteomics can play an important role in advancing the discovery of cancer biomarkers. We aimed to synthesize current evidence concerning proteome signatures and molecular pathways involved in human breast cancer (BC). Our review provides a comprehensive overview of the proteomic profile of patients with BC and may contribute to the understanding of the molecular changes associated with this disease. We highlighted hundreds of proteins, and various molecular pathways involved in BC, which could be considered potential biomarkers involved in the pathophysiology of the disease. Our results may also pave the way for new avenues to explore treatment targets.engCiencias del DeporteNeoplasias de la MamaProteómicaBiomarcadores Tumoralesjournal article10.1016/J.CRITREVONC.2025.104950embargoed accessCiencias médicasCáncerBioquímicaGoal 3: Ensure healthy lives and promote well-being for all at all agesGoal 9: Build resilient infrastructure, promote sustainable industrialization and foster innovation