Hernández García, FrankFernández Iglesias, ÁngelaRodríguez Suárez, JuliánGil Peña, HelenaLópez, José ManuelFuente Pérez, Rocío2025-07-172025-07-172024Hernández-García, F., Fernández-Iglesias, Á., Rodríguez Suárez, J., Gil Peña, H., López, J. M., & Pérez, R. F. (2024). The crosstalk between cartilage and bone in skeletal growth. Biomedicines, 12(12), 2662. https://doi.org/10.3390/biomedicines121226622227-9059https://hdl.handle.net/11268/16032While the flat bones of the face, most of the cranial bones, and the clavicles are formed directly from sheets of undifferentiated mesenchymal cells, most bones in the human body are first formed as cartilage templates. Cartilage is subsequently replaced by bone via a very tightly regulated process termed endochondral ossification, which is led by chondrocytes of the growth plate (GP). This process requires continuous communication between chondrocytes and invading cell populations, including osteoblasts, osteoclasts, and vascular cells. A deeper understanding of these signaling pathways is crucial not only for normal skeletal growth and maturation but also for their potential relevance to pathophysiological processes in bones and joints. Due to limited information on the communication between chondrocytes and other cell types in developing bones, this review examines the current knowledge of how interactions between chondrocytes and bone-forming cells modulate bone growth.engAttribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/CrecimientoPlaca de crecimientoOsteogénesisjournal article10.3390/biomedicines12122662open accessPatalogiaInvestigación médicaGoal 3: Ensure healthy lives and promote well-being for all at all ages