Santalla Hernández, AlfredoMunguía-Izquierdo, DiegoBrea Alejo, LidiaPagola Aldazabal, ItziarDíez Bermejo, JorgeFleck, Steven J.Ara, IgnacioLucía Mulas, Alejandro2015-06-162015-06-162014Santalla, A., Munguía-Izquierdo, D., Brea-Alejo, L., Pagola-Aldazábal, I., Díez-Bermejo, J., Fleck, S. J., ..., & Lucía-Mulas, A. (2014). Feasibility of resistance training in adult McArdle patients: clinical outcomes and muscle strength and mass benefits. Frontiers in Aging Neuroscience, 6, 334.16634365http://hdl.handle.net/11268/4003We analyzed the effects of a 4-month resistance (weight lifting) training program followed by a 2-month detraining period in 7 adult McArdle patients (5 female) on: muscle mass (assessed by DXA), strength, serum creatine kinase (CK) activity and clinical severity. Adherence to training was ≥84% in all patients and no major contraindication or side effect was noted during the training or strength assessment sessions. The training program had a significant impact on total and lower extremities' lean mass (P < 0.05 for the time effect), with mean values increasing with training by +855 g (95% confidence interval (CI): 30, 1679) and +547 g (95%CI: 116, 978), respectively, and significantly decreasing with detraining.engReconocimiento 4.0 Internacionalhttps://creativecommons.org/licenses/by/4.0/deed.es_ESRhabdomyolysisMuscle atrophyMuscle weaknessGlycogenosisjournal article10.3389/fnagi.2014.00334open accessEnfermedades - McArdleEjercicio físicoGenéticaSaludCiencia