First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia

Chabala, ChishalaJacobs, Tom G.Moraleda, CintaNdaferankhande, John M.Mumbiro, VivianPassanduca, AlfeuNamuziya, NatashaTagarro García, AlfredoAarnoutse, Rob E.EMPIRICAL Clinical Trial GroupEt al.2023-11-272023-11-272023Chabala, C., Jacobs, T. G., Moraleda, C., Ndaferankhande, J. M., Mumbiro, V., Passanduca, A., Namuziya, N., Nalwanga, D., Musiime, V., Ballesteros, A., Domínguez-Rodríguez, S., Chitsamatanga, M., Cassia, U., Nduna, B., Bramugy, J., Sacarlal, J., Madrid, L., Nathoo, K. J., Colbers, A., … Manukyan, L. (2023). First-line antituberculosis drug concentrations in infants with hiv and a history of recent admission with severe pneumonia. Journal of the Pediatric Infectious Diseases Society, 12(11), 581-585. https://doi.org/10.1093/jpids/piad0882048-71932048-7207http://hdl.handle.net/11268/12395Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, supporting studies on increased doses of first-line TB drugs in infants.engAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Síndrome de inmunodeficiencia adquiridaSíndrome respiratorio agudo graveAntituberculososFirst-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumoniajournal article10.1093/jpids/piad088open accessAparato respiratorioEnfermedad transmisiblePediatría