Thomma, RobinHalstead, SusanKoning, Laura deWiegers, EvelineGourlay, DawnTio Gillen, AnneRijs, Wouter vanAndersen, HenningAntonini, GiovanniGutiérrez Gutiérrez, GerardoEt. al.2026-02-202026-02-202025Thomma, R. C. M., Halstead, S. K., De Koning, L. C., Wiegers, E. J. A., Gourlay, D. S., Tio-Gillen, A. P., Van Rijs, W., Andersen, H., Antonini, G., Arends, S., Attarian, S., Barroso, F. A., Bateman, K. J., Benedetti, L., Van Den Bergh, P., Bürmann, J., Busby, M., Casasnovas, C., Dardiotis, E., … Zivkovic, S. A. (2025). Large-scale profiling of antibody reactivity to glycolipids in patients with Guillain-Barré syndrome. Brain, 148(11), 4000-4015. https://doi.org/10.1093/brain/awaf1020006-89501460-2156https://hdl.handle.net/11268/16862Guillain-Barré syndrome is an acute polyradiculoneuropathy in which preceding infections often elicit the production of antibodies that target peripheral nerve antigens, principally gangliosides. Anti-ganglioside antibodies are thought to play a key role in the clinical diversity of the disease and can be helpful in clinical practice. Extensive research into clinical associations of individual anti-ganglioside antibody specificities has been performed. Recent research has highlighted glycolipid complexes, glycolipid combinations that may alter antibody binding, as targets. In this study, we investigated antibody reactivity patterns to glycolipids and glycolipid complexes using combinatorial array, in relation to clinical features in Guillain-Barré syndrome.engAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/Enfermedades del sistema nervioso periféricoAutoanticuerposSíndrome de Guillain-Barréjournal article10.1093/brain/awaf102open accessNeurologíaInmunologíaInvestigación médicaGoal 3: Ensure healthy lives and promote well-being for all at all ages