Aguado, CarolinaAlfaro Ruiz, RocíoMartín Belmonte, AlejandroPuertas Avendaño, RicardoFernández, MiriamMartínez Poyato, María LlanosPortero Campillo, EloyPozuelo Montero, MiguelMoreno Martínez, Ana EstherAlonso Gómez, PabloEt. al.Masuo Ohno2025-11-282025-11-282025-11-26Aguado, C., Alfaro-Ruiz, R., Martín-Belmonte, A., Puertas-Avendaño, R., Fernández, M., Martínez-Poyato, M. L., Portero-Campillo, E., Pozuelo-Montero, M., Moreno-Martínez, A. E., Alonso-Gómez, P., Kulik, A., & Luján, R. (2025). Disruption of CaV 2.3 channels in the brain of the 5xFAD mice. Journal of Alzheimer’s Disease, 13872877251396963. https://doi.org/10.1177/138728772513969631387-28771875-8908https://hdl.handle.net/11268/16532CaV2.3 (R-type) channels mediate calcium signals involved in neuronal excitability, synaptic plasticity, and neurotransmitter release in the hippocampus. However, there is currently no information about their potential changes in Alzheimer's disease (AD). This study aims to analyze the protein levels, expression, and subcellular localization of CaV2.3 channels in the hippocampus of 5xFAD mice. Methods.engAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/Bloqueadores del Canal de Sodio Activado por VoltajeCerebroHipocampojournal article10.1177/13872877251396963open accessInvestigación médicaInvestigación sobre el cerebroGoal 3: Ensure healthy lives and promote well-being for all at all ages