Plaza Florido, AbelBrea Alejo, LidiaPérez Prieto, InmaculadaCarrera Bastos, PedroRosado Muñoz, MaríaPagola Aldazabal, ItziarBarranco Gil, DavidSantos Lozano, AlejandroRodríguez Romo, GabrielLucía Mulas, Alejandroet al.2026-07-292026-07-292025Plaza‐Florido, A., Alejo, L. B., Pérez‐Prieto, I., Carrera‐Bastos, P., Muñoz, M. R., Aldazabal, I. P., Barranco‐Gil, D., Santos‐Lozano, A., Rodríguez‐Romo, G., Yanguas‐Casás, N., Radom‐Aizik, S., Lucia, A., & Fiuza‐Luces, C. (2025). Even at 100+: Acute exercise modulates inflammatory pathways in centenarians. Aging Cell, 24(9), e70152. https://doi.org/10.1111/acel.701521474-97181474-9726https://hdl.handle.net/11268/17334Centenarians exhibit remarkable disease resilience despite chronic low-grade inflammation. We investigated the inflammation-related proteome response to acute exercise in seven centenarians (100–104 years). Exercise downregulated 52 proteins (e.g., TNF, IL10, IL1RN, CCL family members) involved in immune cell trafficking, apoptosis, and cytokine regulation. Even at the extreme end of the lifespan, humans retain molecular responsiveness to exercise, with modulation of inflammation-related pathways.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Ciencias del DeporteEnvejecimientoEjercicio Físicojournal article10.1111/ACEL.70152open accessCiencias médicasGerontologíaInmunologíaGoal 3: Ensure healthy lives and promote well-being for all at all ages