Zeng, HaiyanSchagen, Sanne B.Hendriks, Lizza E.L.Sánchez Benavides, GonzaloJaspers, Jaap P. M.Manero, Rosa MaríaLievens, YolandeMurcia Mejía, MauricioKuenen, MarianneCouñago Lorenzo, FelipeEt. al.2025-09-252025-09-252025Zeng, H., Schagen, S. B., Hendriks, L. E. L., Sánchez-Benavides, G., Jaspers, J. P. M., Manero, R. M., Lievens, Y., Murcia-Mejía, M., Kuenen, M., Rico-Oses, M., Albers, E. A. C., Samper, P., Houben, R., De Ruiter, M. B., Dieleman, E. M. T., López-Guerra, J. L., De Jaeger, K., Couñago, F., Lambrecht, M., … Rodríguez De Dios, N. (2025). Impact of HA-PCI on self-reported cognitive functioning and brain metastases in small-cell lung cancer: Pooled findings of NCT01780675 and PREMER trials. Lung Cancer, 199, 108036. https://doi.org/10.1016/j.lungcan.2024.1080361872-83320169-5002https://hdl.handle.net/11268/16212Cognitive decline is an arising concern in patients who need cranial irradiation. We used the pooled longitudinal individual patient data of two phase III trials: NCT01780675 and PREMER to investigate whether hippocampal avoidance (HA)-PCI is associated with improved self-reported cognitive functioning (SRCF) compared with PCI without increasing brain metastases (BM) development within the HA area. Patients with stage I-IV small cell lung cancer (SCLC) were randomized to PCI or HA-PCI. SRCF was assessed and contrast enhanced brain magnetic resonance imaging (MRI) was performed at baseline and up to 24 months follow-up. SRCF and BM incidence after (HA)-PCI were compared between arms. Self reported cognitive impairment was defined as SCRF < 75.engCarcinoma Pulmonar de Células PequeñasMetástasis de la NeoplasiaProtocolo de Ensayo Clínicojournal article10.1016/j.lungcan.2024.108036embargoed accessCáncerAparato respiratorioTratamiento médicoGoal 3: Ensure healthy lives and promote well-being for all at all ages