Cardinal Fernández, PabloMuñoz Rincón, D. A.Thille, Arnaud W.Jaramillo, C.Ballén Barragán, A.Herrero, RaquelNin, NicolásCal, Miguel A. de laEsteban, AndrésLorente Balanza, José Ángel2015-07-172015-07-172014Cardinal-Fernández, P., Muñoz-Rincón, D. A., Thille, A. W., Jaramillo, C., Ballen-Barragán, A., Granados, R., ... & Lorente, J. A. (2014). Acute respiratory distress syndrome sub-phenotypes according to histological findings. Intensive Care Medicine, 40, S10.0342464214321238http://hdl.handle.net/11268/4207The objective is to demonstrate that among patients with the clinical diagnosis of ARDS, the presence of diffuse alveolar damage (DAD) at histological examination, as compared to its absence, defines a clinical sub-phenotype. We studied patients that died in our ICU from 2000 to 2012 with the diagnosis of ARDS according to the Berlin definition and had autopsy. We excluded patients dying [14 days after the diagnosis of ARDS. The diagnosis of DAD required the presence of hyaline membranes plus at least one of the following: intra-alveolar edema, alveolar type I cell necrosis, alveolar type II cell proliferation, interstitial proliferation of fibroblasts or organizing interstitial fibrosis.spaSíndrome de dificultad respiratoria agudajournal article10.1007/s00134-013-3451-5restricted accessAparato respiratorioAparato respiratorio