Martínez Sellés Oliveria Soares, ManuelAlmenar Bonet, LuisPaniagua-Martín, María J.Segovia Cubero, JavierDelgado, Juan F.Arizón del Prado, José MaríaAyesta, AnaLage, ErnestoBrossa, VicensManito Lorite, NicolásPérez Villa, FélixDíaz Molina, BeatrizRábago Juan Aracil, GregorioBlasco-Peiró, TeresaFuente Galán, Luís de laPascual Figal, DomingoGonzález Vílchez, Francisco2015-06-172015-06-172014Martínez‐Sellés, M., Almenar, L., Paniagua‐Martín, M. J., Segovia, J., Delgado, J. F., Arizón, J. M., ..., & González‐Vilchez, F. (2014). Donor/recipient sex mismatch and survival after heart transplantation: only an issue in male recipients? An analysis of the Spanish Heart Transplantation Registry. Transplant International, 28(3), 305-313.14322277http://hdl.handle.net/11268/4017The results of studies on the association between sex mismatch and survival after heart transplantation are conflicting. Data from the Spanish Heart Transplantation Registry. From 4625 recipients, 3707 (80%) were men. The donor was female in 943 male recipients (25%) and male in 481 female recipients (52%). Recipients of male hearts had a higher body mass index (25.9 ± 4.1 vs. 24.3 ± 3.7; P < 0.01), and male donors were younger than female donors (33.4 ± 12.7 vs. 38.2 ± 12.3; P < 0.01). No further relevant differences related to donor sex were detected. In the univariate analysis, mismatch was associated with mortality in men (hazard ratio [HR], 1.18; 95% confidence interval [CI], 1.06–1.32; P = 0.003) but not in women (HR, 0.91; 95% CI 0.74–1.12; P = 0.4). A significant interaction was detected between sex mismatch and recipient gender (P = 0.02). In the multivariate analysis, sex mismatch was associated with long-term mortality (HR, 1.14; 95% CI 1.01–1.29; P = 0.04), and there was a tendency toward significance for the interaction between sex mismatch and recipient gender (P = 0.08). In male recipients, mismatch increased mortality mainly during the first month and in patients with pulmonary gradient >13 mmHg. Sex mismatch seems to be associated with mortality after heart transplantation in men but not in women.engTrasplante de corazónjournal article10.1111/tri.12488open accessCardiologíaSistema cardiovascular