Barrios Tascón, AnaMiura, MasaruDomínguez Rodríguez, SaraFernández Cooke, ElisaSarquella Brugada, GeorgiaTagarro García, AlfredoKAWA-RACE study group2022-07-082022-07-082021Barrios-Tascón, A., Miura, M., Domínguez-Rodríguez, S., Fernández-Cooke, E., Sarquella-Brugada, G., & Tagarro, A. (2021). Ventricular Repolarization Parameters and Coronary Involvement in Kawasaki Disease. The Journal of Pediatrics, 236, 108-112.e5. https://doi.org/10.1016/j.jpeds.2021.05.0230022-34761097-6833http://hdl.handle.net/11268/11435Objectives: To evaluate electrocardiogram markers to predict coronary involvement in patients with Kawasaki disease by assessing measures of ventricular repolarization parameters on the 12-lead electrocardiogram. Study design: This cross-sectional study included 180 Spanish and Japanese patients ≤14 years of age with Kawasaki disease, with or without coronary involvement, from 2011 to 2016. We manually measured the Tp-Te/QT ratio and QTc interval (with Bazett's formula) in 12-lead electrocardiogram in the acute and recovery period and explored their potential association with coronary involvement. Results: No association was found between Tp-Te/QT ratio obtained manually in V5 and V6 leads and coronary involvement in the acute (V5:0.25 [IQR, 0.21-0.27] vs 0.25 [IQR, 0.20-0.27], P = .80; V6:0.24 [IQR, 0.21-0.27] vs 0.25 [IQR, 0.20-0.27], P = .86) or the recovery (V5: 0.23 [IQR, 0.20-0.25] vs 0.23 [IQR, 0.19-0.25], P = .68; V6: 0.23 [IQR, 0.20-0.25] vs 0.23 [IQR, 0.17-0.25], P = .50) period. By contrast, QTc in V5 and V6 was significantly lower in patients with Kawasaki disease and coronary involvement in the acute period (V5: 378 ms [IQR, 364-395 ms] vs 390 ms [IQR, 371-411 ms], P = .04; V6: 377 ms [IQR, 364-392 ms] vs 390 ms [IQR, 371-410 ms], P = .01). A QTc interval of <385 ms in lead V6 was associated with a 2.5-fold increased risk of coronary involvement (OR, 2.5; 95% CI, 1.2-5.3; P = .02). Conclusions: Manually measured QTc interval may be a marker of coronary disease in the acute period of Kawasaki disease.engSíndrome mucocutáneo linfonodularEnfermedad coronariajournal article10.1016/j.jpeds.2021.05.023restricted accessPediatríaEnfermedad cardiovascular