Rubert Aparici, AndreaBagán Debón, Leticia MaríaBagán Sebastián, José Vicente2020-11-252020-11-252020Rubert, A., Bagán, L., & Bagán, J. V. (2020). Oral leukoplakia, a clinical-histopathological study in 412 patients. Journal of Clinical and Experimental Dentistry, 12(6), e540–e546. https://doi.org/10.4317/jced.570911989-5488http://hdl.handle.net/11268/9543Background A retrospective clinical-histopathological study was made of the evolution of oral leukoplakia over time, staging the disease according to the classification of van der Waal. Material and Methods A study was made of 412 patients with oral leukoplakia, analyzing the corresponding clinical factors and histopathological findings; assessing associations between the different clinical presentations and epithelial dysplasia; and evaluating the factors influencing malignant transformation of the lesions. Results Clinically, homogeneous presentations were seen to predominate (n = 336, 81.6%), while histologically most of the lesions exhibited no dysplastic changes (n = 271; 65.7%). Stage 1 of the van der Waal classification was the most common presentation (n = 214; 51.9%). The lesion malignization rate was 8.3%, and the factors associated to a significantly increased malignization risk were non-homogeneous OL lesions (p=0.00), lesion location in the tongue (p=0.00), and the presence of epithelial dysplasia (p=0.00). Conclusions In our series of patients with oral leukoplakia, malignization was associated to the less common clinical presentations of the disease, i.e., non-homogeneous lesions, and the latter tended to exhibit high grade epithelial dysplasia.engjournal article10.4317/jced.57091open accessOdontologíaTerapéuticaOdontologíaTratamiento médico