Gómez Urios, ClaraCortés Fenollar, ClaraLópez Malo, DanielEsteve Mas, María JoséBlesa Jarque, Jesús2026-06-032026-06-032026Gomez-Urios, C., Cortés, C., Lopez-Malo, D., Esteve, M. J., & Blesa, J. (2026). Energy-Efficient Ultrasound-Assisted Extraction of Phenolic Compounds from Orange Peel Using COSMO-RS-Guided Selection of NADES. Food Analytical Methods, 19(8), 229.1936-97511936-976Xhttps://hdl.handle.net/11268/17134Orange peel (OP) is a relevant by-product of the citrus industry, rich in phenolic compounds and ascorbic acid (AA), but its sustainable valorization requires green and efficient extraction strategies. In this study, six natural deep eutectic solvents (NADES) selected via COSMOTherm solubility modelling were evaluated for the recovery of bioactive compounds from OP using ultrasound-assisted extraction (UAE) followed by a stirring treatment. Overall, the study demonstrates that tailored NADES–UAE combinations constitute an effective and sustainable approach for recovering high-value antioxidants from orange peel, contributing to circular economy strategies and green extraction technologies.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Odontología preclínicajournal article10.1007/s12161-026-03141-5open accessCiencias médicasNutriciónTecnología alimentariaGoal 3: Ensure healthy lives and promote well-being for all at all agesGoal 12: Ensure sustainable consumption and production patterns