Rodríguez-Avial, IcíarCulebras, EstherBetriu, CarmenMorales Kucharski, María GraciaPena, IrenePicazo, Juan José2013-11-272013-11-272012Rodríguez-Avial, I., Culebras, E., Betriu, C., Morales, G., Pena, I., & Picazo, J. J. (2012). In vitro activity of tedizolid (TR-700) against linezolid-resistant staphylococci. Journal of Antimicrobial Chemotherapy, 67(1), 167-169.14602091http://hdl.handle.net/11268/929Objectives: To compare the activity of tedizolid (formally known as torezolid and TR-700) with that of 15 agents against a collection of linezolid-resistant staphylococci (164 coagulase-negative staphylococci and 5 Staphylococcus aureus). Methods: Antimicrobial susceptibility tests were performed using the broth microdilution method following the recommendations of the CLSI. Results: All isolates were susceptible to vancomycin and tigecycline. Based on the MIC90 values, the potency of tedizolid against coagulase-negative staphylococci was .16-fold greater than that of linezolid. Tedizolid retained activity against most of the linezolid-resistant staphylococci tested, including multidrug-resistant isolates with elevated linezolid MICs (32 to .128 mg/L). Of the isolates, 79.2% and 31.4% were inhibited by tedizolid at ≤4 mg/L and ≤2 mg/L, respectively. Conclusions: The results of this study confirm the activity of tedizolid against linezolid-resistant staphylococci. This new oxazolidinone could have an important role as a potential therapeutic agent against multidrug-resistant staphylococci.engjournal article10.1093/jac/dkr403restricted accessEnfermedad transmisible