Valenzuela Ruiz, Pedro LuisCarrera Bastos, PedroGonzález Gálvez, BeatrizRuiz Hurtado, GemaOrdovás Muñoz, José MaríaRuilope Urioste, Luis MiguelLucía Mulas, Alejandro2021-01-142021-01-142020Valenzuela, P. L., Carrera-Bastos, P., González Gálvez, B., Ruiz-Hurtado, G., Ordovás, J. M., Ruilope, L. M., & Lucía, A. (2020). Lifestyle interventions for the prevention and treatment of hypertension. Nature reviews. Cardiology. Advance online publication. https://doi.org/10.1038/s41569-020-00437-90008-63121421-9751http://hdl.handle.net/11268/9685Hypertension affects approximately one third of the world's adult population and is a major cause of premature death despite considerable advances in pharmacological treatments. Growing evidence supports the use of lifestyle interventions for the prevention and adjuvant treatment of hypertension. In this Review, we provide a summary of the epidemiological research supporting the preventive and antihypertensive effects of major lifestyle interventions (regular physical exercise, body weight management and healthy dietary patterns), as well as other less traditional recommendations such as stress management and the promotion of adequate sleep patterns coupled with circadian entrainment. We also discuss the physiological mechanisms underlying the beneficial effects of these lifestyle interventions on hypertension, which include not only the prevention of traditional risk factors (such as obesity and insulin resistance) and improvements in vascular health through an improved redox and inflammatory status, but also reduced sympathetic overactivation and non-traditional mechanisms such as increased secretion of myokines.engjournal article10.1038/s41569-020-00437-9restricted accessHipertensiónEstilos de vidaCalidad de vidaEnfermedad cardiovascularEstilo de vidaCalidad de vida