García Tello, AnaAngulo Cuesta, JavierRodriguez-Ubreva, J.Andrés, GuillermoLópez, José IgnacioSánchez-Chapado, ManuelLópez-Ruíz, P.Colás, Begoña2015-07-232015-07-232014García-Tello, A., Angulo, J. C., Rodriguez-Ubreva, J., Andrés, G., López, J. I., Sánchez-Chapado, M., ... & Colás, B. (2014). Prostate anatomy in motheaten viable (me v) mice with mutations in the protein tyrosine phosphatase SHP-1. Actas Urológicas Españolas (English Edition), 38(7), 438-444.0210480616797980http://hdl.handle.net/11268/4240The aim of this paper is to study prostate and seminal vesicle anatomy in viable motheaten (mev) mice with mutations in the PTPN6 gene leading to a severe reduction in the activity of protein tyrosine phosphatase SHP-1. Homozygous mev mice exhibit multiple anomalies that include immunodeficiencies, increased proliferation of macrophage, neutrophil, and erythrocyte progenitors, decreased bone density and sterility. We analyzed macro- and microscopic anatomy of the seminal vesicle and prostate macro- and microscopic anatomy of 5 mev/mev and 8 wt/wt adult 7-week-old mice. Computerized morphometric analysis was performed to measure the relative changes appearing in the epithelial volume of the different prostatic lobes.engPróstataSHP-1journal article10.1016/j.acuroe.2014.06.006restricted accessUrologiaAnatomía