Palao Suay, RaquelAguilar de Armas, María RosaParra Ruiz, F. J.Fernández Gutiérrez, M.Parra, J.Sánchez Rodríguez, CarolinaSanz Fernández, RicardoRodrigáñez Riesco, LauraRomán, J. S.2015-06-192015-06-192015Palao-Suay, R., Aguilar, M. R., Parra-Ruiz, F. J., Fernández-Gutiérrez, M., Parra, J., Sánchez-Rodríguez, C., ... & Román, J. S. (2015). Anticancer and Antiangiogenic Activity of Surfactant-Free Nanoparticles Based on Self-Assembled Polymeric Derivatives of Vitamin E: Structure–Activity Relationship. Biomacromolecules, 16(5), 1566-1581.1525779715264602http://hdl.handle.net/11268/4020α-Tocopheryl succinate (α-TOS) is a well-known mitochondrially targeted anticancer compound, however, it is highly hydrophobic and toxic. In order to improve its activity and reduce its toxicity, new surfactant-free biologically active nanoparticles (NP) were synthesized. A methacrylic derivative of α-TOS (MTOS) was prepared and incorporated in amphiphilic pseudoblock copolymers when copolymerized with N-vinylpyrrolidone (VP) by free radical polymerization (poly(VP-co-MTOS)). The selected poly(VP-co-MTOS) copolymers formed surfactant-free NP by nanoprecipitation with sizes between 96 and 220 nm and narrow size distribution, and the in vitro biological activity was tested. In order to understand the structure-activity relationship three other methacrylic monomers were synthesized and characterized: MVE did not have the succinate group, SPHY did not have the chromanol ring, and MPHY did not have both the succinate group and the chromanol ring.engjournal article10.1021/acs.biomac.5b00130restricted accessVitaminasCáncerSaludCiencias médicasCáncerVitamina