Esteller Collado, GabrielPérez Jover, VirtudesVan-der Hofstadt Román, CarlosMalonda Vidal, ElisabethLlorca Mestre, AnnaPrieto Vila, MaiderCarpallo González, MaríaGonzález Blanch, CésarRuiz Rodríguez, PalomaMoriana, Juan Antonioet al.2025-11-142025-11-142025Esteller-Collado, G., Pérez-Jover, V., Román, C. V. H., Malonda-Vidal, E., Llorca-Mestre, A., Prieto-Vila, M., Carpallo-González, M., González-Blanch, C., Ruíz-Rodríguez, P., Moriana, J. A., Cano-Vindel, A., & Muñoz-Navarro, R. (2025). Effectiveness of a transdiagnostic protocol for anxiety and depression in primary care: The psicap-cv stepped wedge cluster randomized trial. Journal of Anxiety Disorders, 114, 103045. https://doi.org/10.1016/j.janxdis.2025.1030450887-61851873-7897https://hdl.handle.net/11268/16464Anxiety and depressive disorders represent a public health challenge, with high prevalence rates and considerable impact on quality of life (QoL) and functioning. Despite evidence supporting the efficacy of transdiagnostic cognitive behavioural therapy (TD-CBT), its implementation in settings such as primary care (PC) remains limited. The aim of this paper is to analyse the results of the PsicAP-CV, a clinical trial evaluating the effectiveness and implementation of TD-CBT in the PC setting. These findings confirm the efficacy of TD-CBT for treating common mental disorders in PC and point to SW-CRT designs as a feasible and ethically sound avenue for implementing and scaling these evidence-based interventions within public health systems. They also support the broader integration of psychologists into PC, thus offering a scalable model that can significantly improve access to and outcomes of mental health care. Trial registration: EURADICT 2013-001955-11/ISRCTN58437086.engAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/journal article10.1016/j.janxdis.2025.103045open accessCiencias médicasPsicología clínicaPolítica de la saludGoal 3: Ensure healthy lives and promote well-being for all at all agesGoal 4: Quality educationGoal 10: Reduce inequality within and among countries