Ruiz Pomeda, AliciaPárez Sánchez, BelénValls, IsabelPrieto Garrido, Francisco LuisGutiérrez Ortega, Ángel RamónVilla Collar, César2018-02-242018-02-242018Ruiz-Pomeda, A., Pérez-Sánchez, B., Valls, I., Prieto-Garrido, F. L., Gutiérrez-Ortega, R., & Villa-Collar, C. (2018). MiSight Assessment Study Spain (MASS). A 2-year randomized clinical trial. Graefe's Archive for Clinical and Experimental Ophthalmology, 256(5), 1011-1021.0721-832Xhttp://hdl.handle.net/11268/7084To compare myopia progression in children randomized to MiSight contact lenses (CLs) versus children corrected with single-vision spectacles (SV) over a 2-year period. METHODS: Subjects aged 8 to 12 with myopia (-0.75 to -4.00 D sphere) and astigmatism (< -1.00 D cylinder) were assigned to the lens study group (MiSight) or the control group (single vision). Measurements of visual acuity and subjective refraction were taken at 6-month intervals, and axial length, anterior chamber, corneal power, and cycloplegic autorefraction were measured at the baseline, 12-month, and 24-month visits. RESULTS: Eighty-nine subjects were recruited. Forty-fix children were assigned to the MiSight group, and 33 to the single-vision spectacle group. In total, 74 children completed the clinical trial, with the following parameters at the beginning of the study: n =  41 in the MiSight group (age: 11.01 ± 1.23 years, spherical equivalent: -2.16 ± 0.94 D, gender: male: 21, female: 20) and n = 33 in the single-vision group (age: 10.12 ± 1.38 years, spherical equivalent: -1.75 ± 0.94 D, gender: male: 12, female: 21). After 2 years of follow-up, myopia progressed slowly in the MiSight group compared to the control group (0.45 D vs 0.74 D, p < 0.001) and there was less axial elongation in the MiSight group compared to the single-vision group (0.28 mm vs 0.44 mm, p < 0.001). Therefore, use of MiSight CLs produced lower myopia progression (39.32%) and lower axial growth of the eye (36.04%) at 2 years compared to spectacle use. CONCLUSIONS: MiSight contact lens wear reduces axial elongation and myopia progression in comparison to distance single-vision spectacles in children. ClinicalTrials.gov Identifier: NCT01917110.engMiSight contact lensesjournal article10.1007/s00417-018-3906-zrestricted accessLentes de contacto - MaterialesÓpticaOftalmología