Galarregi, CristinaNavas Carretero, SantiagoAngeles Zulet, M.González Navarro, Carlos J.Martínez, J. AlfredoCuevillas, Begoña deMarcos Pasero, HelenaAguilar Aguilar, ElenaReglero, GuillermoAbete, ItziarEt al.2024-06-162024-06-162024Galarregui, C., Navas-Carretero, S., Zulet, M. A., González-Navarro, C. J., Martínez, J. A., De Cuevillas, B., Marcos-Pasero, H., Aguilar-Aguilar, E., Reglero, G., Ramírez De Molina, A., Chausa, P., Iniesta, J. M., Hernando, M. E., Gómez, E. J., García-Rudolph, A., García-Molina, A., Loria-Kohen, V., & Abete, I. (2024). Precision nutrition impact on metabolic health and quality of life in aging population after a 3-month intervention: A randomized intervention. The Journal of Nutrition, Health and Aging, 28(7), 100289. https://doi.org/10.1016/j.jnha.2024.1002891760-47881279-7707http://hdl.handle.net/11268/12925Objectives Innovative precision dietary procedures are required to promote healthy aging. This study aimed to evaluate the effects of a personalised strategy based on the inclusion of individualised foods and digital tools on overall health status and quality of life within a follow-up of 3 months in older adults with overweight or obesity. Methods 127 men and women aged between 50 and 80 years with overweight/obesity participated in the study—between January 2020 and September 2020 at the Center for Nutrition Research-University of Navarra and IMDEA-ALIMENTACIÓN—and were randomly assigned to a usual-care group (standard recommendations) or precision group (precision nutrition strategy based on the inclusion of individualised foods and a mobile application). Anthropometry, body fat percentage, biochemical parameters, diet, and quality of life (SF-36 Health Survey) were assessed at baseline and after 3 months. Results Both strategies were found to improve overall metabolic health; however, the precision approach demonstrated significantly better outcomes. The precision strategy reduced body weight at 3 months (−4.3 kg; p < 0.001) with significant improvements in body fat percentage, blood pressure and general metabolic health (glycated haemoglobin; alanine aminotransferase; aspartate aminotransferase; hepatic steatosis index) in comparison with the standard recommendations. The precision approach significantly enhanced the quality of life (SF-36) of individuals, with additional improvements in emotional well-being (p = 0.024) and vitality (p = 0.008). Adherence to the Mediterranean diet was significantly associated with a higher quality of life and vitality.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article10.1016/j.jnha.2024.100289open accessNutriciónSaludEnfermedadGoal 3: Ensure healthy lives and promote well-being for all at all ages