Clemente Suárez, Vicente JavierMartín Rodríguez, AlexandraCuriel Regueros, AgustínRubio Zarapuz, AlejandroTornero Aguilera, José Francisco2025-05-262025-05-262025Clemente-Suárez, V. J., Martín-Rodríguez, A., Curiel-Regueros, A., Rubio-Zarapuz, A., & Tornero-Aguilera, J. F. (2025). Neuro-Nutrition and Exercise Synergy: Exploring the Bioengineering of Cognitive Enhancement and Mental Health Optimization. Bioengineering, 12(2), 208. https://doi.org/10.3390/bioengineering120202082306-5354http://hdl.handle.net/11268/14654The interplay between nutrition, physical activity, and mental health has emerged as a frontier in bioengineering research, offering innovative pathways for enhancing cognitive function and psychological resilience. This review explores the neurobiological mechanisms underlying the synergistic effects of tailored nutritional strategies and exercise interventions on brain health and mental well-being. Key topics include the role of micronutrients and macronutrients in modulating neurogenesis and synaptic plasticity, theimpact of exercise-induced myokines and neurotrophins on cognitive enhancement, and the integration of wearable bioelectronics for personalized monitoring and optimization. By bridging the disciplines of nutrition, psychology, and sports science with cutting-edgebioengineering, this review highlights translational opportunities for developing targetedinterventions that advance mental health outcomes. These insights are particularly relevant for addressing global challenges such as stress, anxiety, and neurodegenerative diseases. The article concludes with a roadmap for future research, emphasizing the potential ofbioengineered solutions to revolutionize preventive and therapeutic strategies in mentalhealth care.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article10.3390/bioengineering12020208open accessCiencias médicasNeurobiologíaNutriciónGoal 3: Ensure healthy lives and promote well-being for all at all ages