Gómez Talavera, SandraFernández Jiménez, RodrigoFuster, ValentínNothnagel, Nils D.Kouwenhoven, MarcGarcía Lunar, InésCabrera Rodríguez, José ÁngelPizarro, GonzaloIbáñez Cabeza, BorjaSánchez González, JavierEt al.2022-06-222022-06-222021Gómez-Talavera, S., Fernández-Jiménez, R., Fuster, V., Nothnagel, N. D., Kouwenhoven, M., Clemence, M., García-Lunar, I., Gómez-Rubín, M. C., Navarro, F., Pérez-Asenjo, B., Fernández-Friera, L., Calero, M. J., Orejas, M., Cabrera, J. A., Desco, M., Pizarro, G., Ibáñez, B., & Sánchez-González, J. (2021). Clinical Validation of a 3-Dimensional Ultrafast Cardiac Magnetic Resonance Protocol Including Single Breath-Hold 3-Dimensional Sequences. JACC. Cardiovascular Imaging, 14(9), 1742–1754. https://doi.org/10.1016/j.jcmg.2021.02.0311936-878X1876-7591http://hdl.handle.net/11268/11374Objectives: This study sought to clinically validate a novel 3-dimensional (3D) ultrafast cardiac magnetic resonance (CMR) protocol including cine (anatomy and function) and late gadolinium enhancement (LGE), each in a single breath-hold. Background: CMR is the reference tool for cardiac imaging but is time-consuming. Methods: A protocol comprising isotropic 3D cine (Enhanced sensitivity encoding [SENSE] by Static Outer volume Subtraction [ESSOS]) and isotropic 3D LGE sequences was compared with a standard cine+LGE protocol in a prospective study of 107 patients (age 58 ± 11 years; 24% female). Left ventricular (LV) mass, volumes, and LV and right ventricular (RV) ejection fraction (LVEF, RVEF) were assessed by 3D ESSOS and 2D cine CMR. LGE (% LV) was assessed using 3D and 2D sequences. Results: Three-dimensional and LGE acquisitions lasted 24 and 22 s, respectively. Three-dimensional and LGE images were of good quality and allowed quantification in all cases. Mean LVEF by 3D and 2D CMR were 51 ± 12% and 52 ± 12%, respectively, with excellent intermethod agreement (intraclass correlation coefficient [ICC]: 0.96; 95% confidence interval [CI]: 0.94 to 0.97) and insignificant bias. Mean RVEF 3D and 2D CMR were 60.4 ± 5.4% and 59.7 ± 5.2%, respectively, with acceptable intermethod agreement (ICC: 0.73; 95% CI: 0.63 to 0.81) and insignificant bias. Both 2D and 3D LGE showed excellent agreement, and intraobserver and interobserver agreement were excellent for 3D LGE. Conclusions: ESSOS single breath-hold 3D CMR allows accurate assessment of heart anatomy and function. Combining ESSOS with 3D LGE allows complete cardiac examination in <1 min of acquisition time. This protocol expands the indication for CMR, reduces costs, and increases patient comfort.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Imagen por resonancia magnéticaGadoliniojournal article10.1016/j.jcmg.2021.02.031open accessSistema cardiovascularMedicina preventivaTecnología médica