Benítez Agudelo, Juan CamiloClemente Suárez, Vicente JavierClemente Suárez, Vicente JavierNavarro Jiménez, EduardoRestrepo, Dayana2025-09-272025-09-272025Benítez-Agudelo, J. C., Restrepo, D., Navarro-Jimenez, E., & Clemente-Suárez, V. J. (2025). Longitudinal effects of stress in an academic context on psychological well-being, physiological markers, health behaviors, and academic performance in university students. BMC Psychology, 13(1), 753. https://doi.org/10.1186/s40359-025-03041-z2050-7283https://hdl.handle.net/11268/16237Background: Stress in academic settings arises from the interplay between perceived demands such as exams, deadlines, and academic workload and an individual's coping resources. While academic stress (AS) is frequently examined as a separate construct, the stress encountered in an academic environment encompasses both academic and non-academic stressors that students face throughout their university experience. This study examined the longitudinal associations between stress in an academic context on key psychological, physiological, and behavioral variables in university students. Methods: A longitudinal study was conducted with 115 Colombian psychology students aged 16 to 35 years, evaluated at the beginning and end of an academic semester. Variables were measured using validated psychometric questionnaires, including the Big Five inventory, the Zung Depression Scale, the UCLA Loneliness Scale, the State-Trait Anxiety Inventory (STAI), the Acceptance and Action Questionnaire (AAQ-II), the Perceived Stress Scale-4 (PSS-4). Behavioral data, such as physical activity, sleep patterns, and academic performance, were also recorded. Heart rate variability (HRV), a widely used physiological marker of autonomic nervous system function and stress regulation, was assessed. Paired t-tests were used to compare baseline and final measurements, and multiple linear regression determined predictors of academic performance.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article10.1186/s40359-025-03041-zopen accessSueñoEstrés mentalEnfermedad cardiovascularGoal 3: Ensure healthy lives and promote well-being for all at all agesGoal 4: Quality education