Pérez Ruiz, MargaritaMaté-Muñoz, José LuisFoster, CarlRubio, Juan CarlosAndreu, Antoni L.Martín, Miguel ÁngelArenas, JoaquínLucía Mulas, Alejandro2016-08-082016-08-082007Pérez, M., Maté-Muñoz, J. L., Foster, C., Rubio, J. C., Andreu, A. L., Martín, M. A., ... & Lucia, A. (2007). Exercise capacity in a child with McArdle disease. Journal of child neurology, 22(7), 880-882.0883073817088828http://hdl.handle.net/11268/5559We report the exercise capacity of an 8-year-old boy with clinical, histological, biochemical, and genetic evidence of McArdle disease. The patient presented with severe myalgia, proteinuria, hematuria, pyrexia, and elevated creatine kinase after swimming. After pre-exercise ingestion of sucrose, he performed treadmill exercise to symptom limitation. His peak oxygen uptake (18.8 mL/kg/min) and ventilatory threshold (16.0 mL/kg/min) were reduced by 40% and 20% compared with healthy age-matched and gender-matched controls. The results suggest that exercise capacity is reduced early in life in patients with McArdle disease and suggest the need for prophylactic exercise training (following pre-exercise feeding to prevent rhabdomyolysis) to minimize deconditioning.engjournal article10.1177/0883073807304206restricted accessEnfermedades - McArdleMetabolismoDeporte