Montero Magalló, PaulaPérez Leal, MartínPérez Fidalgo, J. A.Sanz, CeliaEstornut Navarro, CristinaRoger Laparra, InésMilara, JavierCervantes, AndrésCortijo, Julio2022-03-032022-03-032022Montero, P., Pérez-Leal, M., Pérez-Fidalgo, J. A., Sanz, C., Estornut, C., Roger, I., Milara, J., Cervantes, A., & Cortijo, J. (2022). Paclitaxel Induces Epidermal Molecular Changes and Produces Subclinical Alterations in the Skin of Gynecological Cancer Patients. Cancers, 14(5), 1146. https://doi.org/10.3390/cancers140511462072-6694http://hdl.handle.net/11268/10881Skin toxicity is one of paclitaxel’s adverse effects. However, its real impact on the skin could be underestimated as these alterations can also appear asymptomatic. We have observed that paclitaxel modifies gene and protein expression of skin markers in a 3D epidermis model, and impairs physical, physiological, and biomechanical properties of the skin in gynecologic cancer patients. These subclinical alterations might be avoided by using prophylactic measures during treatment to prevent possible future adverse reactions.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/OncologíaDermatologiaGinecologíaQuimioterapiajournal article10.3390/cancers14051146open accessFarmacologíaCáncerEnfermedad de la pielSalud de la mujer