Morales Rojas, Javier SalvadorGonzález Vicent, MartaValenzuela Ruiz, Pedro LuisCastillo García, AdriánSantana Sosa, ElenaLassaletta, ÁlvaroSantos Lozano, AlejandroFiuza Luces, María del CarmenLucía Mulas, Alejandro2021-01-142021-01-142020Morales, J. S., González Vicent, M., Valenzuela, P. L., Castillo-García, A., Santana-Sosa, E., Lassaletta, A., Santos-Lozano, A., Fiuza-Luces, C., & Lucía, A. (2020). Tailored Exercise during Hematopoietic Stem Cell Transplantation Hospitalization in Children with Cancer: A Prospective Cohort Study. Cancers, 12(10), 3020. https://doi.org/10.3390/cancers121030202072-6694http://hdl.handle.net/11268/9689We assessed the clinical effects of a supervised exercise (aerobic + resistance) intervention performed during inpatient hospitalization for pediatric hematopoietic stem cell transplantation (HSCT). Patients were placed in an exercise (n = 65 (47 and 18 with allogeneic (allo-) and autologous (auto-) HSCT, respectively)) or a control (n = 53 (39 and 14)) group. Exercise interventions were performed in isolated hospital patient rooms. Patients were followed-up from the beginning of the conditioning phase up to 6 years. We assessed survival, risk of graft-versus-host disease (GvHD) or graft failure (primary outcomes), and engraftment kinetics, supportive care, toxicity profile, and immune reconstitution for auto-HSCT and allo-HSCT. The exercise intervention was safe and did not affect the risk of mortality, acute/chronic GvHD, or graft failure (all p > 0.05). No between-group differences (p > 0.05) were found for the remainder of clinical endpoints, except for a reduced number of total and viral infections in the exercise group after allo-HSCT (unadjusted p = 0.005 for both total and viral infections, and adjusted p = 0.023 and 0.083, respectively). In conclusion, exercise performed during inpatient hospitalization for pediatric HSCT is safe and well tolerated during both auto and allo-HSCT and tends to decrease the risk of infection after allo-HSCT. These findings provide additional support to the notion that a multidisciplinary approach (i.e., including the work of exercise specialists) is suitable in the management of children undergoing HSCT. Further studies are needed to determine whether applying a different training stimulus (notably, higher exercise intensities) exerts positive effects on HSCT prognosis in these patients.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article10.3390/cancers12103020open accessCáncerTerapéuticaEjercicio físicoCáncerTratamiento médicoDeporte