Martín Sánchez-Cantalejo, YolandaSáez Pizarro, BeatrizMonterde, M. I.Murillo, M. T.Fernández Braña, Miguel2013-11-272013-11-272011Martín, Y., Sáez-Pizarro, B., Monterde, M. I., Murillo, M. T., & Fernández-Braña, M. (2011). Synthesis and biological activity of new bispyridinium salts of 4, 4′-bispyridyl-5, 5′-perfluoroalkyl-2, 2′-bisoxazoles. European Journal of Medicinal Chemistry, 46(11), 5662-5667.02235234http://hdl.handle.net/11268/840A series of bispyridinium compounds were synthesized by a short sequence of reactions from symmetric diamides. All compounds were tested for their antiproliferative activity against HT-29, a cell line derived from a human colon adenocarcinoma, and their inhibitory activity against choline kinase (ChoK), a novel anticancer molecular target already in clinical trials. Most of the compounds analyzed showed good antiproliferative activities, in the micromolar range, with the identification of promising lead molecules as a new family of potential inhibitors of ChoK. (C) 2011 Elsevier Masson SAS. All rights reserved.engBisoxazolBispyridiniumAntiproliferativeCholine KinaseInhibitory ActivityCholine Kinase InhibitorsAntiproliferative ActivityNatural-ProductsOxazolesPharmacology & Pharmacyjournal article10.1016/j.ejmech.2011.09.046embargoed accessCáncerTratamiento médico