Gastesi, IratiDomínguez Rodríguez, SaraPrevost, Marthe LeRamírez, AndreaGiaquinto, CarloMesa, María LucíaBallesteros, ÁlvaroJackson, CharlotteVásquez Hoyos, PabloÁlvarez Moreno, CarlosEt al.2025-06-262025Gastesi, I., Domínguez-Rodríguez, S., Le Prevost, M., Ramírez, A., Giaquinto, C., Mesa, M. L., Ballesteros, A., Jackson, C., Vásquez-Hoyos, P., Alvarez Moreno, C., Grasa, C., Epalza, C., Soriano-Arandes, A., Moraleda, C., & Tagarro, A. (2025). Comorbidities Associated With Different Degrees of Severity in Children and Young People Hospitalized With Acute COVID-19. Pediatric Infectious Disease Journal, 44(5), 439-441. https://doi.org/10.1097/INF.00000000000046841532-09870891-3668http://hdl.handle.net/11268/14699In this prospective cohort study with 2326 hospitalized children and young people with coronavirus disease 2019 in Spain and Colombia, 36.4% had comorbidities. Asthma, recurrent wheezing, chronic neurological, cardiac and pulmonary diseases significantly increased the risk of severe outcomes such as death, mechanical ventilation and intensive care unit admission. The incremental risk with additional comorbidities underscores the importance of targeted vaccination strategies for vulnerable children and young people populations.engjournal article10.1097/INF.0000000000004684embargoed accessCiencias médicasEnfermedad transmisibleInfanciaGoal 3: Ensure healthy lives and promote well-being for all at all ages