Sánchez Cuerda, CristinaCuadra, MaríaGamir Henderson, SusanaLobo Abascal, PalomaElices Apellániz, MargaritaCabrera Guerra, Yasmina2022-07-272022-07-272022Sánchez-Cuerda, C., Cuadra, M., Gámir, S., Lobo, P., Elices, M., & Cabrera, Y. (2022). Cervical adenocarcinoma in situ during pregnancy and subsequent fertility-sparing therapy challenge. International Journal of Gynecology and Obstetrics, 158(1), 21-26. https://doi.org/10.1002/ijgo.139481879-34790020-7292http://hdl.handle.net/11268/11541Objective: Adenocarcinoma in situ (AIS) of the cervix is a premalignant lesion, and a precursor of invasive disease. It is less frequent than its squamous counterpart. During pregnancy, AIS is a scarcely described scenario, whose diagnosis barely differs from non-pregnant patients. Its management is challenging with hysterectomy being the definitive treatment. However, its high incidence in young patients makes fertility-sparing management an approachable option for selected patients. The objective of this study is twofold. Firstly, we describe a case of a patient with AIS during pregnancy and the postpartum period. Secondly, the available literature is reviewed. Methods: Retrospective medical record review of a single case and a medical literature search in Pubmed of AIS cases in pregnant women. Results: A 31-year-old woman with cervical AIS diagnosed during pregnancy underwent serial fertility-sparing surgeries including a loop electrosurgical excision procedure and endocervical curettage during the second trimester, and a re-conization and a simple traquelectomy during the postpartum period, until negative margins were achieved. Upon reviewing the literature from 1965 to 2020, 23 other cases were found. Conclusion: Surgical management of cervical AIS during pregnancy is a safe procedure. Subsequent conservative surgeries imply a real challenge to preserve fertility.engColposcopíaPrueba de PapanicolaouDisplasia del cuello del úterojournal article10.1002/ijgo.13948restricted accessSaludEmbarazoCáncer