Martínez Sellés Oliveria Soares, ManuelBruña Fernández, VanesaLacalzada Almeida, JuanDíez Villanueva, PabloRuiz Ortiz, MartínAlzola, ElisabeteArnau, Miguel ÁngelTobar, JavierHernández, Jesús ManuelPérez David, EstherEt al.2022-07-202022-07-202021Martínez-Sellés, M., Bruña, V., Lacalzada-Almeida, J., Díez-Villanueva, P., Ruiz-Ortiz, M., Alzola, E., Arnau, M. Á., Tobar, J., Hernández, J. M., Bonet, A., Castro, V., Rubín, J. M., García-Martín, A., & Pérez-David, E. (2021). Rationale and design of the rigorous atrial analysis in advanced interatrial block (ARABIA) prospective study. Journal of Electrocardiology, 68, 135–140. https://doi.org/10.1016/j.jelectrocard.2021.08.0070022-07361532-8430http://hdl.handle.net/11268/11507Advanced interatrial block (IAB) is present in 10% of subjects ≥75 years and is associated with the risk of clinical events. Methods and results: Prospective multicenter study that will include subjects ≥75 years without exclusion criteria (indication for anticoagulation, cardiac devices, severe valve disease, systolic dysfunction, moderate or severe cognitive impairment, poor echocardiographic window, non-sinus rhythm or partial IAB, stroke, and life expectancy <2 years). A total of 356 subjects, 178 patients with advanced IAB (exposed) and 178 matched individuals with normal P-wave (non-exposed) will be included. Electrocardiogram and advanced transthoracic echocardiography will be performed. Two substudies will include magnetic resonance imaging: cardiac (86 subjects, 43 exposed, and 43 non-exposed) and brain (86 subjects, 43 exposed, and 43 non-exposed). The follow-up will be 2 years. Our main objective is to determine the association of advanced IAB, P-wave duration, and atrial imaging parameters (I] atrial global longitudinal strain, II] maximal left atrial volume index, III] left atrial ejection fraction, IV] left atrial fibrosis - % total left atrial area V] inter- and intra-atrial asynchrony/dyssynchrony) with clinical events (atrial fibrillation, stroke, cognitive impairment, and mortality). The secondary objective is to assess the association of the P-wave duration with atrial imaging parameters and of both with cerebral microemboli in magnetic resonance imaging. Conclusion: Our study will provide data regarding the association of advanced IAB, P-wave duration, and atrial imaging parameters with clinical events. We will also assess the association P-wave duration-atrial imaging parameters-cerebral microemboli.engFibrilación atrialBloqueo interauricularSignos y síntomasjournal article10.1016/j.jelectrocard.2021.08.007restricted accessEnfermedad cardiovascularMedicina preventivaTratamiento médico