García-González, Martín J.Mora Martín, Manuel deLópez Fernández, SilviaLópez Díaz, JavierMartínez Sellés Oliveria Soares, ManuelRomero-García, JoséCordero, MarcoLara Padrón, AntonioMarrero-Rodríguez, FranciscoGarcía-Saiz, María del Mar2014-03-182014-03-182013García-González, M. J., Mora-Martín, M., López-Fernández, S., López-Díaz, J., Martínez-Sellés, M., Romero-García, J., ..., & García-Sáiz, M. M. (2013).Rationale and design of a randomized, double-blind, placebo controlled multicenter trial to study efficacy, security, and long term effects of intermittent repeated levosimendan administration in patients with advanced heart failure: LAICA study. Cardiovascular Drugs and Therapy, 27(6), 573-579.09203206http://hdl.handle.net/11268/2184Advanced heart failure (HF) is associated with high morbidity and mortality; it represents a major burden for the health system. Episodes of acute decompensation requiring frequent and prolonged hospitalizations account for most HF-related expenditure. Inotropic drugs are frequently used during hospitalization, but rarely in out-patients. The LAICA clinical trial aims to evaluate the effectiveness and safety of monthly levosimendan infusion in patients with advanced HF to reduce the incidence of hospital admissions for acute HF decompensation.engjournal article10.1007/s10557-013-6476-7restricted accessEnfermedad cardiovascularTratamiento médico