Álvarez Salvago, FranciscoFigueroa Mayordomo, MaríaMolina García, CristinaPujol Fuentes, ClaraAtienzar Aroca, SandraDiego Moreno, Manuel deMedina Luque, Jose2025-01-262025-01-262025Álvarez-Salvago, F., Figueroa-Mayordomo, M., Molina-García, C., Pujol-Fuentes, C., Atienzar-Aroca, S., de Diego-Moreno, M., & Medina-Luque, J. (2025). Assessing the Relationship of Different Levels of Pain to the Health Status of Long-Term Breast Cancer Survivors: A Cross-Sectional Study. Life, 15(2), 177. https://doi.org/10.3390/life150201772075-1729http://hdl.handle.net/11268/13563Purpose: This study investigated the relationship between different pain levels in the affected arm and health status in long-term breast cancer survivors (LTBCSs) and identified predictors of pain at this stage of long-term survivorship. Methods: A cross-sectional study of 80 participants categorized LTBCSs by pain levels in the affected arm into three groups: no pain (0–0.99), mild pain (1–3.99), and moderate to severe pain (4–10). Variables assessed at least 5 years since diagnosis include pain in the non-affected arm, pain interference, cancer-related fatigue (CRF), physical activity (PA) level, fitness condition, mood state, and health-related quality of life (HRQoL). Results: A total of 36.25% of LTBCSs have no pain, 30% have mild pain, and 33.75% have moderate to severe pain. Furthermore, pain presence was associated with increased pain in the non-affected arm, pain interference, CRF, mood disturbances, and physical inactivity, as well as a decreased HRQoL (all p < 0.05). Regression analysis found “upset by hair loss”, CRF “affective domain”, “dyspnea”, and “alcohol consumption” as significant predictors of higher levels of pain in the affected arm (r2 adjusted = 0.646). Conclusions: A total of 63.75% of LTBCSs continue to experience mild to moderate to severe pain in the affected arm, negatively impacting their physical, mental, and emotional health status, with increased pain severity ≥5 years beyond cancer diagnosis. “Upset by hair loss”, CRF “affective domain”, “dyspnea”, and alcohol consumption collectively explain 64.6% of the affected-arm pain level in LTBCSs.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article10.3390/life15020177open accessCalidad de vidaCáncerRehabilitación médicaGoal 3: Ensure healthy lives and promote well-being for all at all agesGoal 9: Build resilient infrastructure, promote sustainable industrialization and foster innovationGoal 10: Reduce inequality within and among countries