Santos Lozano, AlejandroPlaza Florido, AbelCarrera Bastos, PedroPérez Prieto, InmaculadaHernández Belmonte, AlejandroKamalinejad, FatemehGonzález Gálvez, BeatrizLópez, Juan A.Fleck, Steven J.Lucía Mulas, Alejandroet al.2026-07-162026-07-162026Santos-Lozano, A., Plaza-Florido, A., Carrera-Bastos, P., Pérez-Prieto, I., Hernández-Belmonte, A., Kamalinejad, F., Gálvez, B. G., López, J. A., Lumbreras, J., Rincón-Castanedo, C., Martín-Ruiz, A., Fleck, S. J., López-Soto, A., Yanguas-Casás, N., Pinós, T., Lucia, A., & Fiuza-Luces, C. (2026). Tumor signatures of physical fitness: Insights from a preclinical model. Medicine & Science in Sports & Exercise, 58(1), 35-46. https://doi.org/10.1249/MSS.00000000000038360195-91311530-0315https://hdl.handle.net/11268/17279Cardiorespiratory fitness (CRF) and muscle strength are associated with cancer risk/ mortality in adults. However, there is yet no evidence for pediatric tumors. This study investigated the association of CRF and muscle strength with several tumor-related phenotypes in an aggressive childhood malignancy, high-risk neuroblastoma (HR-NB). Besides the association of CRF with clinical severity of the tumor, distinct novel tumor proteomic signatures associated with CRF and muscle strength were identified, highlighting potential mechanisms linking physical fitness with childhood cancer biology.engCiencias del DeporteNeuroblastomaAptitud FísicaFuerza Muscularjournal article10.1249/MSS.0000000000003836embargoed accessCiencias médicasCáncerBiología molecularGoal 3: Ensure healthy lives and promote well-being for all at all agesGoal 9: Build resilient infrastructure, promote sustainable industrialization and foster innovationGoal 4: Quality education