Manini, ClaudiaLópez Fernández Villaverde, EstíbalizLarrinaga, GorkaLópez, José Ignacio2025-01-032025-01-032024Manini, C., López-Fernández, E., Larrinaga, G., & López, J. I. (2024). Clear cell renal cell carcinoma: A test bench for investigating tumor complexity. Cancers, 16(4), 829. https://doi.org/10.3390/cancers160408292072-6694http://hdl.handle.net/11268/13387Clear cell renal cell carcinoma (CCRCC), by far the most common renal cancer subtype, is an aggressive tumor variant, serving in recent years as a prolific test bench in cancer research. Many of the recent advances in our knowledge about intratumor heterogeneity, tumor evolution, eco-oncology, metastatic competence, and therapeutic resistance have been achieved by analyzing this neoplasm [1–3]. The varied spectrum of papers collected in this Special Issue, composed of five articles, six reviews, one systematic review, and one commentary, confirms this fact.engAttribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/journal article10.3390/cancers16040829open accessCáncerTerapiaInvestigación médicaGoal 3: Ensure healthy lives and promote well-being for all at all ages