Pulido, FedericoDelgado, RafaelPérez-Valero, IgnacioGonzález-García, JuanMiralles, PilarArranz, AlbertoHernando Jeréz, María AsunciónArribas, José R.2013-11-272013-11-272008Pulido, F., Delgado, R., Pérez-Valero, I., González-García, J., Miralles, P., Arranz, A., ..., & Arribas, J. R. (2008). Long-term (4 years) efficacy of lopinavir/ritonavir monotherapy for maintenance of HIV suppression. Journal of Antimicrobial Chemotherapy, 61(6), 1359-1361.http://hdl.handle.net/11268/975Data are scarce on the long-term efficacy of lopinavir/ritonavir monotherapy for the maintenance of HIV suppression. Four years of results of patients randomized to monotherapy in the Only Kaletra (OK) pilot clinical trial are presented. Twenty-one HIV-infected patients with suppressed HIV replication (<50 copies/mL) for at least 6 months and without previous failure while receiving a protease inhibitor-based regimen started lopinavir/ritonavir monotherapy. Follow-up was performed within the OK pilot clinical trial during the first 2 years and according to routine clinical practice during the 3rd and 4th years. Fourteen patients (67%) remain on monotherapy and with RNA <50 copies/mL (intention-to-treat analysis, with missing patients scored as failures). Five patients (24%) had virological rebound and all of them were successfully re-suppressed by adding two nucleosides. No major protease inhibitor mutations were found. Our data support the long-term efficacy and safety of lopinavir/ritonavir monotherapy for the maintenance of HIV suppression, a finding that must be confirmed in larger studies.engjournal article10.1093/jac/dkn103restricted accessSida