Pujol Fuentes, ClaraEeckhaut, BartFernández Carnero, SamuelFernández Sanchís, DanielWein, TheodoreHerrero, PabloSaeys, WimLevin, Mindy2026-05-212026-05-212026Pujol-Fuentes, C., Eeckhaut, B., Fernández Carnero, S., Fernández Sanchís, D., Wein, T., Herrero, P., Saeys, W., & Levin, M. F. (2026). Spinal mechanisms and feasibility of Dry Needling versus Botulinum Toxin Type A in post-stroke lower limb spasticity: A proof-of-concept randomized clinical trial protocol (Stroke-poc). PLOS One, 21(5), e0334571. https://doi.org/10.1371/journal.pone.03345711932-6203https://hdl.handle.net/11268/17116Stroke often causes spasticity, impacting mobility and quality of life. Botulinum Toxin type A and Dry Needling are treatments that reduce spasticity, although Botulinum Toxin type A injections can cause adverse effects. No studies have directly compared their effects at spinal, muscular, functional, quality-of-life, and cost-effectiveness levels. This study aims to determine the spinal mechanisms of BTX-A and DN on post-stroke lower limb spasticity, while also assessing feasibility, safety, and exploratory effects at muscular, functional, quality-of-life, and cost-effectiveness levels.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/FisioterapiaPunción secaToxinas botulínicas tipo AEspasticidad muscularjournal article10.1371/journal.pone.0334571open accessNeurologyMedicina preventivaInvestigación médicaGoal 3: Ensure healthy lives and promote well-being for all at all ages