Muñoz Moreno, DiegoPérez López, GilbertoÁlvarez-Sala Walther, Luis AntonioRueda Camino, José AntonioMartín Vallejo, JavierGonzález Albarrán, Olga2025-03-282025-03-282025Muñoz Moreno, D., Pérez López, G., Álvarez-Sala Walther, L. A., Rueda Camino, J. A., Martín Vallejo, J., & González Albarrán, O. (2025). Clinical profile and management of patients with newly diagnosed type 2 diabetes mellitus in hospital setting. Clinical Medicine Insights, 18, 1-8. https://doi.org/10.1177/117955142513238311179-5514http://hdl.handle.net/11268/14468Background: New-onset type 2 diabetes mellitus (T2DM) is a common clinical scenario in the hospital settings. However, data on the baseline characteristics of these patients at diagnosis in Spain remain limited. Objectives: This study aims to describe the characteristics of 165 patients admitted to a Spanish tertiary hospital with new-onset T2DM. We analysed the use of different treatment regimens at discharge and metabolic control during follow-up. Methods: A retrospective, single-centre cohort study was conducted at General University Gregorio Marañón Hospital, between January 2018 and April 2021. Results: A total of 165 patients participated, with a mean age of 56.4 years, 62.4% of whom were men. Diabetes-related complications were observed in 24.8% of patients at diagnosis. Combined antidiabetic treatment was required in 87% of cases. The mean baseline HbA1c was 10.8%, which decreased by 4.9% after 8 months of follow-up. Conclusion: The clinical heterogeneity and severity of hyperglycaemia in this cohort presented management challenges, in contrast to outpatient settings. Monotherapy was rarely used, with higher adoption of SGLT-2 inhibitors and GLP-1 receptor agonists compared to other studies. Additional research is needed to refine treatment strategies and optimize care for patients with newly diagnosed T2DM.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Diabetes mellitusjournal article10.1177/11795514251323831open accessEndocrinologíaGoal 3: Ensure healthy lives and promote well-being for all at all ages