Garatachea, NuriaMarín, Pedro J.Santos-Lozano, AlejandroSanchís-Gomar, FabiánEmanuele, EnzoLucía Mulas, Alejandro2015-06-232015-06-232015Garatachea, N., Marín, P. J., Santos-Lozano, A., Sanchís-Gomar, F., Emanuele, E., & Lucía, A. (2015). The ApoE Gene Is Related with Exceptional Longevity: A Systematic Review and Meta-Analysis. Rejuvenation research, 18(1), 3-13.1549168415578577http://hdl.handle.net/11268/4026The objective of this meta-analysis was to determine the association of the apolipoprotein E (ApoE) gene with exceptional longevity (EL) (i.e., reaching 100+ years) by identifying possible unequal distribution of alleles/genotypes in the common variants ε2, ε3, and ε4 among centenarians and younger population. The association of ApoE with EL was analyzed in a total of 2776 centenarians (cases) and 11,941 younger controls (from 13 case-control studies) using the chi-squared test with the Yates correction. We conducted combined and separate analyses for all ethnic groups studied in the literature (Caucasian and Asian). The present meta-analysis confirms that, besides its previously documented influence on Alzheimer's and cardiovascular disease risk, the ApoE gene is associated with the likelihood of reaching EL.engjournal article10.1089/rej.2014.1605restricted accessEnvejecimientoGenéticaCienciaEnvejecimientoGenética humana