Alves, MarianaDiego García, Laura deVegliante, GloriaMoreno, ÓscarGil, BeatrizRamos Cabrer, PedroMitra, MeghmaFernández Martín, AnaMenendez Mendez, AidaWang, Yitaoet al.2025-11-042025-11-042025Alves, M., De Diego-Garcia, L., Vegliante, G., Moreno, O., Gil, B., Ramos-Cabrer, P., Mitra, M., Martin, A. F., Menéndez-Méndez, A., Wang, Y., Strogulski, N. R., Sun, M.-J., Melia, C., Conte, G., Plaza-García, S., Khalin, I., Teng, X., Plesnila, N., Klebl, B., … Engel, T. (2025). P2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice. Theranostics, 15(4), 1399-1419. https://doi.org/10.7150/thno.972541838-7640https://hdl.handle.net/11268/16438Post-traumatic epilepsy (PTE) is one of the most common life-quality reducing consequences of traumatic brain injury (TBI). However, to date there are no pharmacological approaches to predict or to prevent the development of PTE. The P2X7 receptor (P2X7R) is a cationic ATP-dependent membrane channel that is expressed throughout the brain. While increasing evidence suggests a role for the P2X7R during seizures and epilepsy, it is unclear if changes in P2X7R expression can predict TBI-induced epilepsy development, and whether P2X7R antagonism can protect against long-lasting brain hyperexcitability caused by TBI. Our results demonstrate the antiepileptogenic potential of P2X7R antagonism to prevent TBI-induced epilepsy and indicate that P2X7R-based PET imaging may be a useful diagnostic tool to identify people at risk of developing PTE.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Epilepsia PostraumáticaReceptores Purinérgicos P2X7journal article10.7150/thno.97254open accessCiencias médicasBiologíaNeurologíaGoal 3: Ensure healthy lives and promote well-being for all at all agesGoal 4: Quality educationGoal 9: Build resilient infrastructure, promote sustainable industrialization and foster innovation