Díaz Gavela, Ana AuroraCerro Peñalver, Elia delAndreu Vázquez, CristinaThuissard Vasallo, Israel JohnSanz Rosa, DavidPeña Huertas, MarinaDuque Santana, VíctorHernández Cortés, GinésGonzález Cortijo, LucíaCouñago Lorenzo, FelipeEt. al2025-12-092025-12-092025Díaz-Gavela, A. A., Del Cerro, E., Sanchez-Garcia, S., Andreu-Vázquez, C., Thuissard-Vasallo, I. J., Sanz-Rosa, D., Pena-Huertas, M., Ruiz-Morales, C., Guerrero-Gomez, L. L., Duque-Santana, V., Hernandez-Cortés, G., Gonzalez-Cortijo, L., & Counago, F. (2025). Smoking increases breast toxicity despite adjuvant hypofractionated IMRT in early breast cancer. Radiation Oncology, 20(1), 45. https://doi.org/10.1186/s13014-025-02614-x1748-717Xhttps://hdl.handle.net/11268/16591The aim of this study is to evaluate the impact of smoking on acute and chronic toxicity in early breast cancer patients treated with hypofractionated intensity-modulated radiation therapy (IMRT) and a brachytherapy boost following breast-conserving surgery. Acute toxicity was assessed at treatment end and chronic toxicity at least one-year post-treatment, using Common Terminology Criteria for Adverse Events v4.0. Statistical analyses included chi-square tests and relative risk (RR) calculations.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Neoplasias de la mamaHipofraccionamiento de la dosis de radiaciónRadioterapia de intensidad moduladajournal article10.1186/s13014-025-02614-xopen accessCáncerTabaquismoInvestigación médicaGoal 3: Ensure healthy lives and promote well-being for all at all ages