Plaza Florido, AbelCarrera Bastos, PedroLucía Mulas, Alejandro2026-07-172026-07-172026Plaza-Florido, A., Carrera-Bastos, P., & Lucia, A. (2026). Exerkine GPLD1 bridges liver and brain. Cell Metabolism, 38(5), 841-843. https://doi.org/10.1016/j.cmet.2026.04.0021550-41311932-7420https://hdl.handle.net/11268/17282A recent study by Bieri et al. shows that exercise elevates hepatic glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1), which cleaves endothelial tissue-nonspecific alkaline phosphatase (TNAP) to rejuvenate cerebrovascular signaling, enhance cognition in aging, and attenuate Alzheimer’s-related pathology. This liver-to-brain enzymatic axis positions hepatokines as potent mediators of exercise-induced neuroprotection, which redefines systemic metabolism as a driver of brain resilience.engCiencias del DeporteEjercicio físicoFosfolipasa DEnvejecimientojournal article10.1016/J.CMET.2026.04.002embargoed accessCiencias médicasNutriciónFisiología humanaGoal 3: Ensure healthy lives and promote well-being for all at all agesGoal 9: Build resilient infrastructure, promote sustainable industrialization and foster innovationGoal 10: Reduce inequality within and among countries