Perdigoto, SusanaMeira e Cruz, MiguelRemesal González, Manuel ÁngelScala, MauroGonzález Soltero, María del RocíoAzpeleta Noriega, ClaraPedro Herráez, Miguel de2026-04-092026-04-092026Perdigoto, S., Meira E Cruz, M., Remesal, M., Scala, M., González Soltero, M. D. R., Noriega, C. A., & De Pedro, M. (2026). Scoping review on the relationship between microRNAs (Mirnas) and short sleep disorder or insomnia with short sleep duration. Sleep Medicine: X, 11, 100184. https://doi.org/10.1016/j.sleepx.2026.1001842590-1427https://hdl.handle.net/11268/17017MicroRNA (miRNA) stands for a class of small, non-coding RNA molecules, typically forming 20 to 25 nucleotides in length, which play a pivotal role in the regulation of gene expression in eukaryotic cells. These molecules are integral to the post-transcriptional regulation of target messenger RNA (mRNA), which they achieve primarily through binding to complementary sequences within the 3′ untranslated region (UTR) of the mRNA. miRNAs exert their regulatory effects by binding to their target mRNA, leading to two primary outcomes: mRNA degradation or inhibition of translation. This functionality positions miRNAs as crucial modulators of a variety of biological processes, including cell growth, differentiation, apoptosis, and responses to environmental stress. Furthermore, dysregulation of miRNA expression is associated with pathological conditions, including cancer, cardiovascular disease, and neurological disorders. They are associated with sleep regulation and are helpful in diagnosing diseases, including sleep disturbances. This scoping review aims to summarize existing literature in patients aged 18 to 65 with a main diagnosis of Short Sleep Disorder (SSD), and Insomnia with Short Sleep Duration (ISOSS) and its relationship with miRNAs. The objective of this study is to search for existing evidence on the composition (presence, diversity, and relative abundance) of miRNAs in individuals with and without sleep disturbances, and to know whether the cardiometabolic comorbidities associated with these pathologies imply miRNA alterations.enghttps://creativecommons.org/licenses/by/4.0/BiomedicinaMicroARNsTrastornos del Sueño-VigiliaRevisión de Alcancejournal article10.1016/j.sleepx.2026.100184open accessSueñoCáncerInvestigación médicaAttribution 4.0 InternationalGoal 3: Ensure healthy lives and promote well-being for all at all ages