Santiago Dorrego, CatalinaRuiz, Jonatan R.Muniesa Ferrero, Carlos AlbertoGonzález-Freire, MartaGómez Gallego, FélixLucía Mulas, Alejandro2013-11-272013-11-272010Santiago-Dorrego, C., Ruiz, J. R., Muniesa-Ferrero, C. A., González‐Freire, M., Gómez‐Gallego, F., & Lucía-Mulas, A. (2010). Does the polygenic profile determine the potential for becoming a world‐class athlete? Insights from the sport of rowing. Scandinavian Journal of Medicine & Science in Sports, 20(1), e188-e194.09057188http://hdl.handle.net/11268/664We determined whether the polygenic profile computed with seven candidate polymorphisms (i.e., ACE, ACTN3, AMPD1, CKMM, HFE, GDF-8 and PPARGC1A) for endurance performance is different in 39 world-class and 15 national-class Spanish (Caucasian) lightweight rowers. The second purpose was to examine the impact of possessing a "preferable" polygenic profile on the sport success in terms of the number of medals won in World and National Championships. Finally, we also compared the polygenic profile of world- and national-class Spanish rowers with that of the general Spanish population. The polygenic profile did not differ between groups of rowers. We did not observe an association between having a preferable polygenic profile and medals won in World and National Championships. Finally, we observed that rowers tend to have a more "favorable" polygenic profile than the general Spanish population. These findings argue against the idea that genetic endowment differentiates athletic champions from elite, yet less accomplished athletes. In contrast, we cannot discard the fact that, overall, elite athletes are endowed with a more "favorable" polygenic profile than the general population.engMultifactorial Inheritance*Polymorphism, Genetic*Sports/*PhysiologyEuropean Continental Ancestry Group/GeneticsGenotypeHumansMalePhysical Endurance/PhysiologySpainjournal article10.1111/j.1600-0838.2009.00943.xrestricted accessGenética humanaFisiología humanaAtleta