García Escrivá, DavidPérez Silvestre, JoséNúñez, JulioCasado, JesúsMorales Rull, José LuisSánchez Marteles, MartaConde Martel, AliciaLlácer, PauSalamanca Bautista, PradoPlasín, Miguel Ángelet al.2026-06-082026-06-082026García-Escrivá, D., Pérez-Silvestre, J., Núñez, J., Casado, J., Luís Morales-Rull, J., Sánchez-Marteles, M., Conde-Martel, A., Llàcer, P., Salamanca-Bautista, P., Plasín, M. Á., Manuel Cerqueiro, J., Gil, P., Manzano, L., Formiga, F., & Trullàs, J. C. (2026). Serum chloride and the response to hydrochlorothiazide in patients with acute heart failure: A post-hoc analysis from the CLOROTIC trial. Revista Española de Cardiología (English Edition), S1885585726001040. https://doi.org/10.1016/j.rec.2026.04.0061885-5857https://hdl.handle.net/11268/17147Hypochloremia is associated with worse prognosis and diuretic resistance in acute heart failure (AHF). This study investigated whether serum chloride is associated with the efficacy and safety of hydrochlorothiazide in patients with AHF. In patients with AHF, the addition of hydrochlorothiazide to loop diuretics enhances decongestion regardless of the baseline serum chloride.engMedicinajournal article10.1016/j.rec.2026.04.006embargoed accessCiencias médicasEnfermedad cardiovascularFarmacologíaGoal 3: Ensure healthy lives and promote well-being for all at all ages